The Fluorinase fromStreptomyces cattleya Is Also a Chlorinase
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چکیده
منابع مشابه
Probing the molecular determinants of fluorinase specificity.
Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold activity improvement), and conferred novel activity towards substrates not readil...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2006
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.200503582